Most of the cases of spider bite are harmless and non-toxic. It mainly causes local reactions and only rarely, systemic effects are reported. We here report a case of a spider bite from Eastern India presenting with hemolysis and acute renal failure. The patient needed urgent hemodialysis, blood transfusion and finally fasciotomy for local edema. Fortunately she fully recovered with no sequelae. As far as we could search, this is probably the first report of this complication from India. This case report highlights the potentially dangerous effects of insect bite and the need for follow up.