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Simple Spectrophotometric Determination of Esomeprazole Magnesium in Pharmaceutical Formulations

Asian Journal of Pharmaceutical and Health Sciences,2011,1,3,135-136.
Published:August 2011
Type:Short Communication
Abstract:

A simple, fast and reliable spectrophotometric method was developed for determination of esomeprazole magnesium in pharmaceutical formulations. The method is based on the reaction of esomeprazole magnesium with bromocresol green, the formed ion pair complex extracted into chloroform at pH 3.5. The chloroform extractable layer is measured at 420 nm against reagent blank. Beer's law obeyed in concentration of 50-250 5g/ml of esomeprazole magnesium. The method is validated statistically.

Optical characteristics of proposed methods