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Synthesis of Some Alkoxylated Pyrazoles

Asian Journal of Pharmaceutical and Health Sciences,2011,1,2,75-78.
Published:May 2011
Type:Research Article
Abstract:

The synthesis of pyrazoles: 1-(3, 4, 5-trimethoxyphenyl)- 3-(2, 4-dimethoxy phenyl) dihydropyrazole was executed by reaction of hydrazine hydrate with chalcones followed by concomitant dehydration and cyclization. The structure of the synthesized compounds were elucidated using infrared, nuclear magnetic resonance (1H and 13C), and mass spectrometry. The chalcones and pyrazoles were screened for antibacterial activities using the agar- well diffusion method at a serial dilution of 106cfu/ml. The pyrazoles showed no significant bacteriocidal or bacteriostatic activity against the clinical isolates and typed culture of bacteria tested against.

Schemes of Synthesis of Pyrazoles