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Formulation Of Transdermal Drug Delivery System Of Metoprolol Tartrate And Its Evaluation

Asian Journal of Pharmaceutical and Health Sciences,2011,1,1,22-25.
Published:February 2011
Type:Research Article
Authors:
Abstract:

The oral bioavailability of Metoprolol tartrate is poor, different matrix-type transdermal films containing Metoprolol tartrate was formulated with an objective to study the effect of polymers on the release characters. The polymers selected were cellulose acetate butyrate(CAB), polyvinyl pyrrolidone (PVP), ethyl cellulose (EC), and hydroxy propyl methyl cellulose (HPMC).The films were formulated using different blends of the polymers by solvent casting method. The physico chemical evaluation of the polymer matrices was performed for suitability.The interaction among various components of the matrices was studied by performing fourier transform infrared spectroscopy and thin layer chromatography. In-vitro permeation studies of ideal films were performed using Franz diffusion cell. The results revealed the amount of drug released in a steady state and in a controlled manner.

Figure showing Percentage of Drug Release of selected Filims