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Simultaneous Estimation Of Telmisartan And Hydrochlorothiazide In Pharmaceutical Dosage Form

Asian Journal of Pharmaceutical and Health Sciences,2011,1,1,12-15.
Published:February 2010
Type:Research Article
Authors:
Abstract:

A simple, accurate, fast and precise simultaneous analytical method has been developed for simultaneous determination of Telmisartan and Hydrochlorothiazide in tablet dosage form. The wavelengths selected for these drugs were 296 nm and 270 nm respectively. The linearity at selected wavelength lies between 2 10 5g/ml for Telmisartan and 4 20 5g/ml for Hydrochlorothiazide. The concentrations of these drugs were evaluated in laboratory mixture of reference standard and different marketed formulation. Recovery studies confirmed the accuracy of proposed method. Precision of method was found out as the values within acceptable limit. Thus the proposed method and results were validated as per ICH guidelines. Statistical analysis proves that the method is reproducible and selective for the simultaneous estimation of Telmisartan and Hydrochlorothiazide.

Overlain spectra of Telmisartand and Hydrochlorothazide