2012 / VOL-02, ISSUE-03, JULY-SEPTEMBER 2012

Synthesis and biological screening of N-Substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide

By  Aziz-ur-rahman

Research Articles

Page:  384-389


In the present study, a series of N-substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide has been synthesized. The reaction of benzylamine (1) with 4-chlorobenzenesulfonyl chloride (2) yielded the parent compound N-benzyl-4-chlorobenzenesulfonamide (3), which further on treatment with different electrophiles (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). The structure 1 of synthesized compounds has been established by IR, H-NMR and EI-MS. All the compounds have been screened for their antimicrobial activity.

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ISSN: 2321-3965

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