Archives

2012 / VOL-02, ISSUE-03, JULY-SEPTEMBER 2012

Synthesis and biological screening of N-Substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide

By  Aziz-ur-rahman

Research Articles

Page:  384-389

Abstract

In the present study, a series of N-substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide has been synthesized. The reaction of benzylamine (1) with 4-chlorobenzenesulfonyl chloride (2) yielded the parent compound N-benzyl-4-chlorobenzenesulfonamide (3), which further on treatment with different electrophiles (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). The structure 1 of synthesized compounds has been established by IR, H-NMR and EI-MS. All the compounds have been screened for their antimicrobial activity.

 Download Complete Article ⇓⇓ 

Visits: 439 Downloads:10

AJPHS

ISSN: 2321-3965

© Copyright @ AJPHS. All right reserved.Designed By IRSYS