Archives2016 / VOL-6,ISSUE-04,OCTOBER-DECEMBER 2016
Clinicopathological characteristics of triple negative breast cancer and its correlation with prognostic markers:Analysis in a tertiary care center
By Asaranti Kar,Bidyut Prava Das,Priyadarshini Biswal
Introduction: Triple negative breast cancer is defined as breast cancer with negative immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR) & Her2neu.These cancers have more aggressive clinical course, poor prognosis and distinctive metastatic pattern. They account for 10-17 % of all breast cancers. The management of these cases is challenging and needs extensive research to establish their relationship with basal like breast cancer. This study was undertaken with an objective to know the incidence of triple negative breast cancer in our population and analyze them with respect to different clinicopathological parameters and determine biological behaviour which can help in proper management of these patients. Material & method: The study was conducted in Department of Pathology, S.C.B. Medical College , Cuttack from July 2015 to december 2016. This is a prospective study carried out to determine clinical characteristics of triple negative breast cancer including age, family history of breast , endometrial ,ovarian or stomach cancer. Tumour pathology was reviewed to determine histologic type, grade , staging and IHC status. Result: Of 341 patients diagnosed with breast cancer, 112 (32%) were identified to be triple negative breast cancer. Majority cases were seen in 4th-5th decades of life with adverse pathological characteristics of high histological grade (42%) and frequent nodal metastasis (60%). Conclusion: We conclude that triple negative breast cancer is common in 4th to 5th decades of life, with adverse biological behaviour suggested by high histologic grade and frequent nodal metastasis. Further research regarding BRCA status and other IHC parameters is required to subcategorise triple negative breast cancer into different prognostic groups.