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2016 / VOL-6,ISSUE 01,JANUARY-MARCH 2016

Chitosan-alginate microparticles of Andrographispaniculata and Annona muricata extracts for Controlled Release

By  Matthew I. Arhewoh, Augustine O. Okhamafe1*, Finizia Auriemma2, Claudio De Rosa andRocco Di Girolamo

Research Articles

Page:  1377-1383

Abstract

This study investigates the properties of microparticles prepared from Andrographispaniculata(AP) and Annona muricata(AM) aqueous extracts for controlled release.Extracts obtained by maceration of the dried powdered plant leaves were microencapsulated by counterion coacervation method. Microcapsules were characterized using Fourier-transform infrared-spectroscopy (FTIR), x-ray difractometry (XRD) and differential scanning calorimetry (DSC).In vitro release studies were carried out at pH 1.2 for 2 h and 6.8 for a further 10 h.Release was monitored at274 and 230 nm for AM and AP, respectively. Encapsulation efficacy was less than 52% for AP and 70% for AM. Invitro drug release at pH 1.2 showed less than 40% releasefrom the microcapsules after 2h while over 90% of extract was released after 6h at pH 6.8. Conventional capsules released the content within 1 h in simulated gastric fluid.FTIR, XRD and DSC results indicatethe stable character of the extract within the microcapsules.Microencapsulation with chitosan-alginate controlled the release of Andrographis paniculata (AP) and Annona muricata (AM) aqueous extracts

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