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2014 / VOL-04, ISSUE-02, APRIL-JUNE 2014

Formulation and evaluation of ofloxacin microspheres using natural gum polymers

By  R,Nethaji

Research Articles

Page:  1006-1012

Abstract

Ofloxacin is a fluoroquinolones antibacterial agent with a broad spectrum of activity against gram positive and negative bacteria. It is used in urinary and respiratory tract infections, gonorrhea and skin. Conventional doses vary from 200-600mg twice or thrice a day, as per severity of infection and its biologicalhalf-lifeis5-6hrs. In present study, Ofloxacin microspheres were formulated using polymer and natural gums such as Guar gum and Xanthan gum as rate controlling material by ionic cross- linking technique with an aim to prolong its release. All formulations prepared by using differentdrug-polymerratios, were evaluated for relevant parameters. Depending upon thedrug-polymerratio of Guar gum, the percentage yield and encapsulation efficiency of microspheres were found to range between 89.17±6.02 to 94.61±4.95% and 78.40±5.08 to 83.89±4.17% respectively. Also the drug to polymer ratio of Xanthan gum, the percentage yield and encapsulation efficiency were found to range between 90.12±6.22 to 93.02±5.39% and 65.52±4.27 to 72.73±3.88%, respectively. All prepared Microspheres were spherical, discrete and compact in shape and size distribution was between44.32-50.17µm.In-vitrostudies were carried out at different pH for a period of 12 hours. Guar gum (GG3) formulations was 93.26% and Xanthan gum (XG3) was 82.54% for better sustained release. Stability studies of selected ofloxacin microspheres showed good results. It could be also concluding that the all the formulations were shown satisfactory results.

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